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Travel health.
Clearly explained.

Atovaquone/proguanil

Atovaquone/proguanil is a daily prescription medicine used to prevent malaria in destinations where it is recommended.

What is it?

Malaria is a potentially fatal infection transmitted by Anopheles mosquitoes. Symptoms can begin during travel or after returning and require urgent testing.

Where it may be relevant

  • Travellers visiting a malaria-risk area where atovaquone/proguanil is recommended
  • Shorter trips where the seven-day post-travel course may be preferable
  • Adults and children meeting the product's age and weight requirements

Dose schedules.

The clinician will select the appropriate licensed schedule after reviewing age, health, previous doses and departure date.

Daily prevention

Adults and weight-eligible children

Before travelStart 1–2 days before
During travelTake daily
After travelContinue for 7 days

Take at the same time each day with food or a milky drink.

Who may be eligible

  • People whose itinerary, medical history and medicines support this option
  • Children prescribed the correct tablet strength and dose for their weight

Who may not be eligible

  • People with severe renal impairment for malaria prevention
  • Anyone allergic to atovaquone, proguanil or an ingredient
  • Pregnancy, breastfeeding a low-weight infant, vomiting, diarrhoea and interacting medicines require individual review

Potential side effects

  • Nausea, stomach pain, diarrhoea or headache
  • Mouth ulcers, cough or dizziness can occur
  • Taking each dose with food or a milky drink improves absorption

Important risks and precautions

  • No antimalarial guarantees complete protection; bite avoidance remains essential
  • Vomiting soon after a dose may require another dose and clinical advice
  • Fever during travel or within a year of return requires urgent medical assessment and a clear travel history

Clinical references

Further information.

Information is general and does not replace a personal assessment, prescribing decision or the latest destination-specific advice.

Frequently asked questions

How do I take atovaquone/proguanil?

Start one to two days before entering the malaria area, take it every day while exposed and continue for seven days after leaving.

Is atovaquone/proguanil the same as Malarone?

Malarone is a brand containing atovaquone and proguanil. Suitable generic products contain the same active ingredients.

Can children take it?

Children can use an appropriate product when they meet the minimum weight requirement. The dose is calculated by weight.

What if I vomit after taking a tablet?

A replacement dose may be needed if vomiting occurs soon after a dose. Seek advice and also manage persistent vomiting because absorption may be unreliable.

Does it prevent every case of malaria?

No. Use bite precautions and seek urgent testing for fever during travel or after returning.